N-Ethylmaleimide → 2-Azido-n-ethylsuccinimide

HRID 1059488ノート

反応式

HRID 1059488 の反応式
[CH2:1]([N:3]1[C:7](=[O:8])[CH:6]=[CH:5][C:4]1=[O:9])[CH3:2].[NH:10]=[N+:11]=[N-:12].C1(=O)NC(=O)C=C1>C1(C)C=CC=CC=1>[N:10]([CH:5]1[CH2:6][C:7](=[O:8])[N:3]([CH2:1][CH3:2])[C:4]1=[O:9])=[N+:11]=[N-:12]

参加物

5

反応物 3

HCID 4362N-EthylmaleimideHCID 10935Maleimide2 回HCID 24530Hydrazoic acid

生成物 1

HCID 101763002-Azido-n-ethylsuccinimide収率 93%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

反応条件

温度
-30 °C

実験手順

A solution in toluene of N-ethylmaleimide, HN3 (excess relative to the maleimide), and the (salen)AlN3 catalyst depicted above (10 mol % relative to the maleimide) was maintained at −30° C. for 18 h. After a standard quench and work-up of the reaction mixture, the crude material was purified to yield 2-azido-N-ethylsuccinimide (93%, 93% ee).

後処理

  1. customAfter a standard quench
  2. customwork-up of the reaction mixture, the crude material was purified

出典と根拠

ORDレコード
ord-6c57a816806d4646804325a4aacefeaa
出典データセット
uspto-grants-2003_02
特許番号
US06521561B1

反応ノート

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