Trifluoroacetic acid → 3-(Hydroxycarbonylmethyl)-5-(4-trifluoromethyl-3-pyridyl)-1,2,4-oxadiazole

HRID 1059497ノート

反応式

HRID 1059497 の反応式
C([O:5][C:6]([CH2:8][C:9]1[N:13]=[C:12]([C:14]2[CH:15]=[N:16][CH:17]=[CH:18][C:19]=2[C:20]([F:23])([F:22])[F:21])[O:11][N:10]=1)=[O:7])(C)(C)C.FC(F)(F)C(O)=O>ClCCl>[OH:7][C:6]([CH2:8][C:9]1[N:13]=[C:12]([C:14]2[CH:15]=[N:16][CH:17]=[CH:18][C:19]=2[C:20]([F:22])([F:23])[F:21])[O:11][N:10]=1)=[O:5]

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 227440793-(Tert-butoxycarbonylmethyl)-5-(4-trifluoromethyl-3-pyridyl)-1,2,4-oxadiazole

生成物 1

HCID 227440893-(Hydroxycarbonylmethyl)-5-(4-trifluoromethyl-3-pyridyl)-1,2,4-oxadiazole収率 78.7%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

12.4 g of 3-(tert-butoxycarbonylmethyl)-5-(4-trifluoromethyl-3-pyridyl)-1,2,4-oxadiazole are dissolved in 110 ml of dichloromethane and admixed with 57 ml of trifluoroacetic acid. The reaction mixture is stirred at room temperature for 1.5 hours and subsequently concentrated under reduced pressure. The residue is repeatedly taken up in dichloromethane and reconcentrated to remove any remaining trifluoroacetic acid. The mixture is finally triturated with diethyl ether, giving 8.1 g of the product as a white solid.

後処理

  1. concentrationsubsequently concentrated under reduced pressure
  2. customto remove any remaining trifluoroacetic acid
  3. customThe mixture is finally triturated with diethyl ether

出典と根拠

ORDレコード
ord-56c651e600014db3bd7aa15ed135e385
出典データセット
uspto-grants-2003_02
特許番号
US06521610B2

反応ノート

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