Trifluoroacetic acid → Isoindoline-5-carbonitrile
反応式
C(OC([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13]([C:17]#[N:18])[CH:14]=2)[CH2:9]1)=O)(C)(C)C.FC(F)(F)C(O)=O>ClCCl>[C:17]([C:13]1[CH:14]=[C:15]2[C:10](=[CH:11][CH:12]=1)[CH2:9][NH:8][CH2:16]2)#[N:18]参加物
4
反応条件
- 温度
- 40 °C
実験手順
A mixture of 2-(tert-butyloxycarbonyl)-5-cyano-2,3-dihydro-1H-isoindole (7.6 g) and trifluoroacetic acid (20 ml) in dichloromethane (200 ml) was heated at 40° C. for 0.5 h, then cooled and evaporated in vacuo and the residue partitioned between dichloromethane and 2M sodium hydroxide. The aqueous phase was re-extracted with dichloromethane and the combined organics dried and evaporated to give the title compound as a pink solid (4.24 g, 94%).
後処理
- temperaturecooled
- customevaporated in vacuo
- customthe residue partitioned between dichloromethane and 2M sodium hydroxide
- extractionThe aqueous phase was re-extracted with dichloromethane
- customthe combined organics dried
- customevaporated
出典と根拠
- ORDレコード
- ord-b72684da16574146b15d0f3a6239c5e5
- 出典データセット
- uspto-grants-2003_02
- 特許番号
- US06521638B1
反応ノート
読み込み中…