Hydrazine hydrate (1:1) → HCID 178428485、化合物
反応式
Cl.Cl.[CH3:3][C:4]1[N:5]=[C:6]([NH:16][C:17](=[NH:21])SCC)[S:7][C:8]=1[C:9]1[CH:14]=[C:13]([CH3:15])[CH:12]=[CH:11][N:10]=1.O.[NH2:23][NH2:24]>C(O)C>[CH3:3][C:4]1[N:5]=[C:6]([NH:16][C:17]([NH:23][NH2:24])=[NH:21])[S:7][C:8]=1[C:9]1[CH:14]=[C:13]([CH3:15])[CH:12]=[CH:11][N:10]=1参加物
4
反応条件
- 温度
- 80 °C
実験手順
To a suspension of N-(4-methyl-5-(4-methylpyridin-2-yl)thiazol-2-yl)-S-ethylisothiourea dihydrochloride (36.5 mg) in ethanol (0.5 ml) was added hydrazine hydrate (50 mg). The mixture was stirred at 80° C. for 1 hour and cooled to ambient temperature. The precipitate was collected by filtration, washed with ethanol, water and diisopropyl ether to give N-(4-methyl-5-(4-methylpyridin-2-yl)thiazol-2-yl)-N′-aminoguanidine (11 mg).