3-(4-Methylpyridin-2-yl)nitrobenzene → 2-(3-Aminophenyl)-4-methylpyridine

HRID 1059924ノート

反応式

HRID 1059924 の反応式
[CH3:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([C:8]2[CH:9]=[C:10]([N+:14]([O-])=O)[CH:11]=[CH:12][CH:13]=2)[CH:3]=1>C(O)C.[Pd]>[CH3:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([C:8]2[CH:9]=[C:10]([CH:11]=[CH:12][CH:13]=2)[NH2:14])[CH:3]=1

参加物

4

反応物 1

HCID 128111223-(4-Methylpyridin-2-yl)nitrobenzene

生成物 1

HCID 186676162-(3-Aminophenyl)-4-methylpyridine収率 98.8%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

A suspension of 3-(4-methylpyridin-2-yl)nitrobenzene (100 mg) in ethanol (2 ml) was hydrogenated over palladium on carbon (10% w/w, 50% wet, 10 mg) under a hydrogen atmosphere for 3 hours. The catalyst was filtered off, and the filtrate was evaporated under reduced pressure to give 3-(4-methylpyridin-2-yl)aniline (85 mg).

後処理

  1. filtrationThe catalyst was filtered off
  2. customthe filtrate was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-208ecb5c84814deb92796c10a9b41c0a
出典データセット
uspto-grants-2003_02
特許番号
US06521643B1

反応ノート

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