Methanol → 2-Methoxy-5-morpholinoaniline

HRID 1060339ノート

反応式

HRID 1060339 の反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]2[CH2:14][CH2:13][O:12][CH2:11][CH2:10]2)=[CH:5][C:4]=1[N+:15]([O-])=O.CO>ClCCl.[Pd]>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]2[CH2:10][CH2:11][O:12][CH2:13][CH2:14]2)=[CH:5][C:4]=1[NH2:15]

参加物

5

反応物 2

HCID 887MethanolHCID 177470104-(4-Methoxy-3-nitrophenyl)morpholine

生成物 1

HCID 113677782-Methoxy-5-morpholinoaniline収率 88%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 6344Dichloromethane溶媒

実験手順

4-(4-Methoxy-3-nitro-phenyl)-morpholine (6 g) is hydrogenated in dichloromethane (100 ml) and methanol (600 ml) using palladium on carbon (10%, 600 mg) for 12 hours. The catalyst is removed by filtration and the solution evaporated in vacuo. Purification by flash chromatography (silica, eluent ethyl acetate/n-hexane 1:1, then) affords the product as off-white solid (4.6 g, 88%). MS: m/e=209 (M+H+).

後処理

  1. customfor 12 hours
  2. customThe catalyst is removed by filtration
  3. customthe solution evaporated in vacuo
  4. customPurification by flash chromatography (silica, eluent ethyl acetate/n-hexane 1:1

出典と根拠

ORDレコード
ord-a03a0e3a55ad40808e7897d28c811f15
出典データセット
uspto-grants-2003_02
特許番号
US06521754B2

反応ノート

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