ホームMCPワークベンチSkills
ホームワークベンチ通知マイページ
llms.txt · MCPガイドプライバシーポリシー · 利用規約 · サポートv1.8.0
  1. ホーム
  2. /反応

Potassium Carbonate → [5-Methyl-2-[3-(trifluoromethyl)-1h-pyrazol-1-yl]-4-pyrimidinyl][3-(trifluoromethyl)phenyl]methanone

HRID 1060527
ノート
印刷プレビュー

反応式

HRID 1060527 の反応式
Cl[C:2]1[N:7]=[C:6]([C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([C:16]([F:19])([F:18])[F:17])[CH:11]=2)=[O:9])[C:5]([CH3:20])=[CH:4][N:3]=1.[F:21][C:22]([F:29])([F:28])[C:23]1[CH:27]=[CH:26][NH:25][N:24]=1.C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[CH3:20][C:5]1[C:6]([C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([C:16]([F:19])([F:18])[F:17])[CH:11]=2)=[O:9])=[N:7][C:2]([N:25]2[CH:26]=[CH:27][C:23]([C:22]([F:29])([F:28])[F:21])=[N:24]2)=[N:3][CH:4]=1
参加物実験手順後処理出典と根拠反応ノート

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 18070343-(Trifluoromethyl)pyrazoleHCID 18628524(2-Chloro-5-methyl-4-pyrimidinyl)[3-(trifluoromethyl)phenyl]methanone

生成物 1

HCID 18628526[5-Methyl-2-[3-(trifluoromethyl)-1h-pyrazol-1-yl]-4-pyrimidinyl][3-(trifluoromethyl)phenyl]methanone収率 16.3%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile
溶媒

実験手順

The title compound of Step A (0.6 g, 2 mmol), 3-trifluoromethylpyrazole (0.25 g), and potassium carbonate (0.8 g, 6 mmol) were suspended in acetonitrile (15 mL) and heated at reflux for 3 h. The cooled reaction mixture was filtered and the cake washed with acetonitrile. After evaporation of the solvent under reduced pressure, the residue was subjected to silica gel chromatography using hexanes/ethyl acetate (85:15) to give 0.12 g of the title compound of Step B, a compound of the invention, as a white solid. 1H NMR (CDCl3/200 MHz) 2.45 (s, 3H), 6.75 (d, 1H), 7.67 (d, 1H), 7.92 (d, 1H), 8.10 (s, 1H), 8.27 (s, 1H), 8.54 (d, 1H), 8.9 (s, 1H).

後処理

  1. temperatureheated
  2. temperatureat reflux for 3 h
  3. customThe cooled reaction mixture
  4. filtrationwas filtered
  5. washthe cake washed with acetonitrile
  6. customAfter evaporation of the solvent under reduced pressure

出典と根拠

ORDレコード
ord-0937343c6c8b4ab09c59e494c9bdf640
出典データセット
uspto-grants-2003_02
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US06525001B1

反応ノート

読み込み中…

このページの内容参加物実験手順後処理出典と根拠反応ノート