Potassium thiocyanate → Fluorenylmethyloxycarbonyl isothiocyanate

反応式

[C:1]1([CH2:14][O:15][C:16](Cl)=[O:17])[C:13]2[CH2:12][C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:5]=2[CH:4]=[CH:3][CH:2]=1.[S-:19][C:20]#[N:21].[K+]>>[C:1]1([CH2:14][O:15][C:16]([N:21]=[C:20]=[S:19])=[O:17])[C:13]2[CH2:12][C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:5]=2[CH:4]=[CH:3][CH:2]=1

参加物

反応物 2

HCID 516872Potassium thiocyanate

HCID 14261773Fluorenylmethyl chloroformate

生成物 1

HCID 22346806Fluorenylmethyloxycarbonyl isothiocyanate

実験手順

The title compound was prepared from Fluorenylmethyloxycarbonyl chloride and potassium thiocyanate according to the procedure of Kearney et al. J. Org. Chem. 1998, 63, 199; 1H NMR (CDCl3) δ7.75 (d, J=7.5 Hz, 2H), 7.56 (d, J=7.5 Hz, 2H), 7.41 (t, J=7.5 Hz, 2H), 7.32 (t, J=7.5 Hz, 2H), 4.44 (d, J=7.4 Hz, 2H), 4.23 (t, J=7.4 Hz, 1H).

出典と根拠

ORDレコード: ord-73501eb1a30843bebd953fa381615423
出典データセット: uspto-grants-2003_02
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06525061B1

反応ノート

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