Oxalyl chloride → HCID 18628711、化合物
反応式
[CH:1]1([CH2:7][CH:8]([C:12]([O:14][CH2:15][CH3:16])=[O:13])[C:9](O)=[O:10])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.C(Cl)(=O)C([Cl:20])=O>C(OCC)(=O)C.CN(C=O)C>[Cl:20][C:9]([CH:8]([CH2:7][CH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1)[C:12]([O:14][CH2:15][CH3:16])=[O:13])=[O:10]参加物
5
反応条件
- 温度
- 0 °C
実験手順
A solution comprised of 3-cyclohexyl-2-ethoxycarbonylpropionic acid (8.52 g, 37 mmol) in ethyl acetate (80 mL) was cooled to 0° C. was treated sequentially with 2 drops of DMF and oxalyl chloride (3.93 mL) added dropwise over five minutes. The mixture was allowed to warm slowly and after approximately 2 hours concentrated to provide ethyl 2-chlorocarbonyl-3-cyclohexylpropionate.
後処理
- additionadded dropwise over five minutes
- temperatureto warm slowly and after approximately 2 hours
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-6e70474a5b134023af8ce676ac455290
- 出典データセット
- uspto-grants-2003_02
- 特許番号
- US06525036B2
反応ノート
読み込み中…