2-Fluoro-4-(1-hydroxy-1-pyridin-3-yl-methyl)-benzonitrile → 2-Fluoro-4-(1-pyridin-3-yl-methanoyl)-benzonitrile
反応式
[F:1][C:2]1[CH:9]=[C:8]([CH:10]([OH:17])[C:11]2[CH:12]=[N:13][CH:14]=[CH:15][CH:16]=2)[CH:7]=[CH:6][C:3]=1[C:4]#[N:5]>C(Cl)Cl.O=[Mn]=O>[F:1][C:2]1[CH:9]=[C:8]([C:10]([C:11]2[CH:12]=[N:13][CH:14]=[CH:15][CH:16]=2)=[O:17])[CH:7]=[CH:6][C:3]=1[C:4]#[N:5]参加物
4
実験手順
2-Fluoro-4-(1-hydroxy-1-pyridin-3-yl-methyl)-benzonitrile (1.04 g, 4.55 mmol) and MnO2 (3.96 g, 45.5 mmol) were stirred in CH2Cl2 (100 mL) for 4 h. The solution was filtered through a celite pad and concentrated to give the title compound.
後処理
- filtrationThe solution was filtered through a celite pad
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-cd9fa62e3ee24648aad97c11615e0db5
- 出典データセット
- uspto-grants-2003_02
- 特許番号
- US06525074B2
反応ノート
読み込み中…