3-(3-Methoxy-benzenesulfonylamino)-propionic acid → N-(3-hydroxy-propyl)-3-methoxy-benzenesulfonamide

HRID 1060894ノート

反応式

HRID 1060894 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([S:9]([NH:12][CH2:13][CH2:14][C:15](O)=[O:16])(=[O:11])=[O:10])[CH:6]=[CH:7][CH:8]=1>C1COCC1>[OH:16][CH2:15][CH2:14][CH2:13][NH:12][S:9]([C:5]1[CH:6]=[CH:7][CH:8]=[C:3]([O:2][CH3:1])[CH:4]=1)(=[O:11])=[O:10]

参加物

3

反応物 1

HCID 186294403-(3-Methoxy-benzenesulfonylamino)-propionic acid

生成物 1

HCID 18629442N-(3-hydroxy-propyl)-3-methoxy-benzenesulfonamide

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

3-(3-Methoxy-benzenesulfonylamino)-propionic acid (0.755 g, 2.91 mmol), was dissolved in THF (10 mL), cooled in an ice-H2O bath, and treated with borane THF complex (3.49 mL of a 1M solution, 3.49 mmol) with stirring. After warming to room temperature over 1 h, the reaction was cooled in an ice bath, and quenched by dropwise addition of H2O, then partitioned between H2O and CH2Cl2. The aqueous layer was washed with CH2Cl2 (3×20 mL), dried (MgSO4). Filtration and concentration in vacuo gave the title compound which was used without further purification.

後処理

  1. temperaturecooled in an ice-H2O bath
  2. temperaturethe reaction was cooled in an ice bath
  3. customquenched by dropwise addition of H2O
  4. custompartitioned between H2O and CH2Cl2
  5. washThe aqueous layer was washed with CH2Cl2 (3×20 mL)
  6. dry with materialdried (MgSO4)
  7. filtrationFiltration and concentration in vacuo

出典と根拠

ORDレコード
ord-a79f9991b4fe44e892010678ab2e9673
出典データセット
uspto-grants-2003_02
特許番号
US06525074B2

反応ノート

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