Sodium Hydroxide → {[(4-{4-[((2R)-2-Hydroxy-2-{4-hydroxy-3-[(methylsulfonyl)amino]phenyl}ethyl)amino]-1-piperidineyl}anilino)carbonyl]amino}acetic acid

HRID 1061420

反応式

HRID 1061420 の反応式
[OH:1][C@H:2]([C:27]1[CH:32]=[CH:31][C:30]([OH:33])=[C:29]([NH:34][S:35]([CH3:38])(=[O:37])=[O:36])[CH:28]=1)[CH2:3][NH:4][CH:5]1[CH2:10][CH2:9][N:8]([C:11]2[CH:26]=[CH:25][C:14]([NH:15][C:16]([NH:18][CH2:19][C:20]([O:22]CC)=[O:21])=[O:17])=[CH:13][CH:12]=2)[CH2:7][CH2:6]1.[OH-].[Na+]>>[OH:1][C@H:2]([C:27]1[CH:32]=[CH:31][C:30]([OH:33])=[C:29]([NH:34][S:35]([CH3:38])(=[O:36])=[O:37])[CH:28]=1)[CH2:3][NH:4][CH:5]1[CH2:10][CH2:9][N:8]([C:11]2[CH:12]=[CH:13][C:14]([NH:15][C:16]([NH:18][CH2:19][C:20]([OH:22])=[O:21])=[O:17])=[CH:25][CH:26]=2)[CH2:7][CH2:6]1

参加物

3

反応物 2

HCID 14798Sodium HydroxideHCID 86584576Ethyl {[(4-{4-[((2R)-2-hydroxy-2-{4-hydroxy-3-[(methylsulfonyl)amino]phenyl}-ethyl)amino]-1-piperidineyl}anilino)carbonyl]amino}acetate

生成物 1

HCID 69654942{[(4-{4-[((2R)-2-Hydroxy-2-{4-hydroxy-3-[(methylsulfonyl)amino]phenyl}ethyl)amino]-1-piperidineyl}anilino)carbonyl]amino}acetic acid

実験手順

The title compound was prepared from ethyl {[(4-{4-[((2R)-2-hydroxy-2-{4-hydroxy-3-[(methylsulfonyl)amino]phenyl}ethyl)amino]-1-piperidineyl}anilino)carbonyl]-amino}acetate (which was obtained in Example 377) by NaOH hydrolysis as a white solid; 1H NMR (300 MHz, DMSO-d6) δ 1.35-1.55 (m, 2H), 1.80-2.00 (m, 2H), 2.50-2.90 (m, 5H), 2.92 (s, 3H), 3.30-3.50 (m, 2H), 3.59 (d, J=5.9 Hz, 2H), 4.60 (dd, J=8.8, 3.5 Hz, 1H), 6.14 (t, J=5.0 Hz, 1H), 6.80 (d, J=9.1 Hz, 2H), 6.84 (d, J=8.3 Hz, 1H), 7.03 (dd, J=8.3, 2.0 Hz, 1H), 7.15-7.25 (m, 3H), 8.54 (s, 1H); MS (ES) m/z: 520.3 (M−H)−; HRMS Calcd. for C23H32N5O7S(MH+): 522.2017. Found: 522.2000.

出典と根拠

ORDレコード
ord-19c7af7732b74731879829d0a4432789
出典データセット
uspto-grants-2003_02
特許番号
US06525202B2

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