Hydrochloric Acid → {(3RS)-4-Acetyl-3-isopropyl-2-oxo-6-phenyl-1,2,3,4-tetrahydropyrazin-1-yl}acetic acid

HRID 1061673ノート

反応式

HRID 1061673 の反応式
[OH-].[Li+].[C:3]([N:6]1[CH:11]=[C:10]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[N:9]([CH2:18][C:19]([O:21]CC)=[O:20])[C:8](=[O:24])[CH:7]1[CH:25]([CH3:27])[CH3:26])(=[O:5])[CH3:4].Cl>C(O)C>[C:3]([N:6]1[CH:11]=[C:10]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[N:9]([CH2:18][C:19]([OH:21])=[O:20])[C:8](=[O:24])[CH:7]1[CH:25]([CH3:27])[CH3:26])(=[O:5])[CH3:4]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 21302833Ethyl {(3RS)-4-acetyl-3-isopropyl-2-oxo-6-phenyl-1,2,3,4-tetrahydropyrazine-1-yl}acetate

生成物 1

HCID 22284314{(3RS)-4-Acetyl-3-isopropyl-2-oxo-6-phenyl-1,2,3,4-tetrahydropyrazin-1-yl}acetic acid

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A 4 N aqueous lithium hydroxide solution (0.4 ml) is added to a solution of ethyl {(3RS)-4-acetyl-3-isopropyl-2-oxo-6-phenyl-1,2,3,4-tetrahydropyrazin-1-yl}acetate (185 mg, Reference compound No. 50-1) in ethanol (5 ml), and the mixture is stirred for 35 minutes. To the reaction mixture is added 1 N hydrochloric acid to acidify the system, and the whole is extracted with ethyl acetate. The extract is washed with saturated brine and dried over anhydrous magnesium sulfate. The extract is concentrated under reduced pressure to give the titled reference compound (167 mg).

後処理

  1. extractionthe whole is extracted with ethyl acetate
  2. washThe extract is washed with saturated brine
  3. dry with materialdried over anhydrous magnesium sulfate
  4. concentrationThe extract is concentrated under reduced pressure

出典と根拠

ORDレコード
ord-dd6bc8da0bd54efdbad36ff9f2863d88
出典データセット
uspto-grants-2005_11
特許番号
US06960575B2

反応ノート

読み込み中…