Trifluoroacetic acid → 2-[7-(4-Fluoro-phenyl)-4-oxo-4,5-dihydro-1H-benzo[b][1,4]diazepin-2-yl]-thiophene-3-carbonitrile

HRID 1062192ノート

反応式

HRID 1062192 の反応式
C(OC(=O)[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:19]=[CH:18][C:17]([F:20])=[CH:16][CH:15]=2)=[CH:10][C:9]=1[NH:21][C:22](=[O:33])[CH2:23][C:24]([C:26]1[S:27][CH:28]=[CH:29][C:30]=1[C:31]#[N:32])=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[F:20][C:17]1[CH:18]=[CH:19][C:14]([C:11]2[CH:12]=[CH:13][C:8]3[NH:7][C:24]([C:26]4[S:27][CH:28]=[CH:29][C:30]=4[C:31]#[N:32])=[CH:23][C:22](=[O:33])[NH:21][C:9]=3[CH:10]=2)=[CH:15][CH:16]=1

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 86588039{3-[3-(3-Cyano-thiophen-2-yl)-3-oxo-propionylamino]-4'-fluoro-biphenyl-4-yl}-carbamic acid tert.-butyl ester

生成物 1

HCID 222245712-[7-(4-Fluoro-phenyl)-4-oxo-4,5-dihydro-1H-benzo[b][1,4]diazepin-2-yl]-thiophene-3-carbonitrile

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Prepared from {3-[3-(3-cyano-thiophen-2-yl)-3-oxo-propionylamino]-4′-fluoro-biphenyl-4-yl}-carbamic acid tert.-butyl ester (Example K54) by treatment with TFA in CH2Cl2 according to the general procedure M. Obtained as an orange solid (209 mg).

出典と根拠

ORDレコード
ord-442adf5c8b4c4e5aa3bc7ac35642dc8f
出典データセット
uspto-grants-2005_11
特許番号
US06960578B2

反応ノート

読み込み中…