Hydrochloric Acid → 1-(2-Fluoro-ethyl)-[1,4]diazepane

HRID 1062563ノート

反応式

HRID 1062563 の反応式
C(OC([N:8]1[CH2:14][CH2:13][CH2:12][N:11]([CH2:15][CH2:16][F:17])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:18]>O1CCCC1>[ClH:18].[ClH:18].[F:17][CH2:16][CH2:15][N:11]1[CH2:12][CH2:13][CH2:14][NH:8][CH2:9][CH2:10]1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 222814761-Tert-butoxycarbonyl-4-(2-fluoroethyl)homopiperazine

生成物 1

HCID 222813171-(2-Fluoro-ethyl)-[1,4]diazepane収率 97%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

A mixture of 1-tert-butoxycarbonyl-4-(2-fluoroethyl)homopiperazine (550 mg, 2.23 mmol) in 10% aqueous hydrochloric acid (2 mL) and tetrahydrofuran (4 mL) was stirred at room temperature for 2 h, and the reaction mixture was evaporated to dryness under vacuum. Resulting residue was triturated from Et2O/MeOH to afford the titled compound (475 mg, 97%) as a white solid.

後処理

  1. customthe reaction mixture was evaporated to dryness under vacuum
  2. customResulting residue was triturated from Et2O/MeOH

出典と根拠

ORDレコード
ord-b37d5a242b594f0dba95ceb4880f5266
出典データセット
uspto-grants-2005_11
特許番号
US06962911B2

反応ノート

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