Ethanol → 2-Phenyl-1,2,3,4-tetrahydroquinoline

HRID 1062581

反応式

HRID 1062581 の反応式
[C:1]1([C:7]2[CH:16]=[CH:15][C:14]3[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=3)[N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C(O)C.[Na]>O>[C:1]1([CH:7]2[CH2:16][CH2:15][C:14]3[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=3)[NH:8]2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

参加物

5

反応物 3

HCID 702EthanolHCID 715452-Phenylquinoline2 回HCID 5360545Sodium

生成物 1

HCID 107529152-Phenyl-1,2,3,4-tetrahydroquinoline

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

In Scheme A, step 2, the 2-phenyl-1,2,3,4-tetrahydroquinoline of formula (3) is prepared by reducing 2-phenylquinoline of formula (2). For example, 2-phenylquinoline of formula (2) is dissolved in a suitable alcoholic solvent, such as absolute ethanol. Sodium metal is then added and the reaction is allowed to cool to room temperature. The reaction mixture may then be diluted with water and extracted with a suitable organic solvent, such as methylene chloride, ethyl acetate, or chloroform. The combined extracts may then be washed with water and brine, the organic layer is separated and dried and the solvent is evaporated in vacuo to provide the 2-phenyl-1,2,3,4-tetrahydroquinoline of formula (3) which may be used without further purification.

後処理

  1. customIn Scheme A, step 2, the 2-phenyl-1,2,3,4-tetrahydroquinoline of formula (3) is prepared
  2. extractionextracted with a suitable organic solvent, such as methylene chloride, ethyl acetate, or chloroform
  3. washThe combined extracts may then be washed with water and brine
  4. customthe organic layer is separated
  5. customdried
  6. customthe solvent is evaporated in vacuo

出典と根拠

ORDレコード
ord-209114e7ea504d76ac9ea7df8e82e714
出典データセット
uspto-grants-2005_11
特許番号
US06962928B2

関連ノート

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