Hydrochloric Acid → 4-PHENYL-1-PIPERAZINECARBOTHIOAMIDE

HRID 1062648ノート

反応式

HRID 1062648 の反応式
[C:1]1([N:7]2[CH2:12][CH2:11][N:10]([C:13]([NH:15]C(=O)OCC)=[S:14])[CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl.[OH-].[Na+]>>[C:1]1([N:7]2[CH2:8][CH2:9][N:10]([C:13](=[S:14])[NH2:15])[CH2:11][CH2:12]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 1518349ETHYL (4-PHENYL-1-PIPERAZINYL)CARBOTHIOYLCARBAMATE

生成物 1

HCID 20517984-PHENYL-1-PIPERAZINECARBOTHIOAMIDE収率 63%

反応条件

温度
80 °C

実験手順

Ethyl (4-phenyl-1-piperazinyl)carbothioylcarbamate (13 g, 44 mmol) was added to conc. hydrochloric acid (44 mL) and the mixture was stirred at 80° C. for 2 h. The reaction mixture was made basic with 8N aqueous sodium hydroxide solution and the crystals were collected by filtration. The crystals were washed with water and dried to give the title compound (6.1 g, yield 63%).

後処理

  1. filtrationthe crystals were collected by filtration
  2. washThe crystals were washed with water
  3. customdried

出典と根拠

ORDレコード
ord-39c6e7e35fd646cc9aeb751855e24757
出典データセット
uspto-grants-2005_11
特許番号
US06962933B1

反応ノート

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