Acetic Acid → HCID 12732175、化合物
反応式
C([N:8]1[CH2:12][CH2:11][CH2:10][C@@H:9]1[C:13]([OH:16])([CH3:15])[CH3:14])C1C=CC=CC=1.CC(O)=O>CO.[OH-].[OH-].[Pd+2]>[NH:8]1[CH2:12][CH2:11][CH2:10][C@@H:9]1[C:13]([OH:16])([CH3:15])[CH3:14]参加物
5
実験手順
A mixture of (R)-2-(1-benzyl-pyrrolidin-2-yl)-propan-2-ol (582 mg, 2.65 mmol), HOAc (3 mL), and Pd(OH)2/C (200 mg) in MeOH was shaken in a Parr bottle with H2 under 50 psi for 24 h. The reaction mixture was then filtered through celite eluting with MeOH. HCl (g) was passed through the filtrate, and the filtrate was then concentrated to afford the title compound as a gray solid (419 mg, 95%). MS: 130.1 (MH+); HPLC Rf: n.d.; HPLC purity: n.d.
後処理
- filtrationThe reaction mixture was then filtered through celite
- washeluting with MeOH
- concentrationthe filtrate was then concentrated
出典と根拠
- ORDレコード
- ord-76e1fa9b19ce4659b8aa95f8ad343f37
- 出典データセット
- uspto-grants-2005_11
- 特許番号
- US06964961B2
反応ノート
読み込み中…