1-Carbethoxy-4-ethylamino-3-methylpiperidine → 4-Ethylamino-3-methylpiperidine

HRID 1063285ノート

反応式

HRID 1063285 の反応式
C([N:6]1[CH2:11][CH2:10][CH:9]([NH:12][CH2:13][CH3:14])[CH:8]([CH3:15])[CH2:7]1)(OCC)=O>[OH-].[Na+]>[CH2:13]([NH:12][CH:9]1[CH2:10][CH2:11][NH:6][CH2:7][CH:8]1[CH3:15])[CH3:14]

参加物

3

反応物 1

HCID 222789001-Carbethoxy-4-ethylamino-3-methylpiperidine

生成物 1

HCID 222788594-Ethylamino-3-methylpiperidine

試薬・触媒・溶媒 1

HCID 14798Sodium Hydroxide溶媒

反応条件

温度
110 °C

実験手順

1-Carbethoxy-4-ethylamino-3-methylpiperidine (2.3 g, 10.74 mmol) was suspended in 5 M NaOH solution (15 ml), stirred at 110° C. for 120 hr, cooled, extracted with ethyl acetate, dried (Na2SO4) and concentrated to dryness to afford 4-ethylamino-3-methylpiperidine. Yield 0.7 g (46%), C8H18N2, m/z 143, (M+1).

後処理

  1. temperaturecooled
  2. extractionextracted with ethyl acetate
  3. dry with materialdried (Na2SO4)
  4. concentrationconcentrated to dryness

出典と根拠

ORDレコード
ord-e1ccf03a55d244148de004fe9edac073
出典データセット
uspto-grants-2005_11
特許番号
US06964966B2

反応ノート

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