Sulfuric Acid → 2,4-Dichloro-6-methylnicotinic acid
反応式
[Cl:1][C:2]1[C:7]([C:8]([O:10]CC)=[O:9])=[C:6]([Cl:13])[CH:5]=[C:4]([CH3:14])[N:3]=1.[OH-].[Na+].OS(O)(=O)=O>O.CO>[Cl:1][C:2]1[C:7]([C:8]([OH:10])=[O:9])=[C:6]([Cl:13])[CH:5]=[C:4]([CH3:14])[N:3]=1参加物
6
実験手順
A solution of commercially available (Maybridge) ethyl 2,4-dichloro-6-methylpyridine-3-carboxylate (1.0 g, 4.3 mmol) and NaOH (342 mg, 8.6 mmol) in water (1.7 mL) and MeOH (1.5 mL) was heated to 80° C. for 4 h. The mixture was acidified using 50% H2SO4 and then filtered. The solid collected was washed with cold water and dried to give of 2,4-dichloro-6- methylpyridine-3-carboxylic acid (582 mg, 66%): LCMS RT: 0.70 min, MH+: 206.2.
後処理
- filtrationfiltered
- customThe solid collected
- washwas washed with cold water
- customdried
出典と根拠
- ORDレコード
- ord-06d36c2a63fd461f9a6496719ec71814
- 出典データセット
- uspto-grants-2005_11
- 特許番号
- US06964971B2
反応ノート
読み込み中…