4-Acetylbenzoic Acid → 4-[3e-(2-Fluoro-4-thiophen-2-yl-phenyl)-acryloyl]-benzoic acid

HRID 10636

反応式

HRID 10636 の反応式
[F:1][C:2]1[CH:9]=[C:8]([C:10]2[S:11][CH:12]=[CH:13][CH:14]=2)[CH:7]=[CH:6][C:3]=1[CH:4]=O.[C:15]([C:18]1[CH:26]=[CH:25][C:21]([C:22]([OH:24])=[O:23])=[CH:20][CH:19]=1)(=[O:17])[CH3:16]>>[F:1][C:2]1[CH:9]=[C:8]([C:10]2[S:11][CH:12]=[CH:13][CH:14]=2)[CH:7]=[CH:6][C:3]=1/[CH:4]=[CH:16]/[C:15]([C:18]1[CH:26]=[CH:25][C:21]([C:22]([OH:24])=[O:23])=[CH:20][CH:19]=1)=[O:17]

参加物

3

反応物 2

HCID 114704-Acetylbenzoic AcidHCID 167686082-Fluoro-4-(thiophen-2-yl)benzaldehyde

生成物 1

HCID 210416174-[3e-(2-Fluoro-4-thiophen-2-yl-phenyl)-acryloyl]-benzoic acid収率 71%

実験手順

The title compound was prepared by condensing 2-fluoro-4-thiophen-2-yl-benzaldehyde (Ex-30A) and 4-acetylbezoic acid in a similar manner as described in Ex-3. Yellow solid, 71% yield, m.p.>260° C. 1H-NMR (300 MHz, d6-DMSO): 8.19 (d, 2H, J=8.4 Hz), 8.12 (d, 1H, J=8 Hz), 8.06 (d, 2H, J=8 Hz), 7.95 (d, 1H, J=16 Hz), 7.80 (d, 1H, J=16 Hz), 7.71 (d, 1H, J=3.5 Hz), 7.62 (m, 2H), 7.56 (d, 1H, J=8 Hz), 7.15 (m, 1H). MS m/z=352 ([M]+, 100%). HRMS (EI) Calcd. for C20H13NO3S: 352.0569. Found: 352.0560.

出典と根拠

ORDレコード
ord-8fc2ef8a042a46f58b067fa79d0eba07
出典データセット
uspto-grants-2006_08
特許番号
US07094801B2

関連ノート

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