Allyl bromide → 3-Bromo-4-fluorophenyl allyl ether

HRID 1063846

反応式

HRID 1063846 の反応式
[Br:1][C:2]1[CH:3]=[C:4]([OH:9])[CH:5]=[CH:6][C:7]=1[F:8].[CH2:10](Br)[CH:11]=[CH2:12].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[CH2:12]([O:9][C:4]1[CH:5]=[CH:6][C:7]([F:8])=[C:2]([Br:1])[CH:3]=1)[CH:11]=[CH2:10]

参加物

5

反応物 3

HCID 7841Allyl bromideHCID 11430Potassium CarbonateHCID 27833813-Bromo-4-Fluorophenol

生成物 1

HCID 221447733-Bromo-4-fluorophenyl allyl ether収率 61%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

A mixture of 0.65 gm (3.43 mMol) 3-bromo-4-fluorophenol, 0.60 mL (6.86 mMol) allyl bromide, and 0.71 gm (5.15 mMol) potassium carbonate in 6 mL acetone was stirred at reflux for 13 hours. The reaction mixture was concentrated under reduced pressure and the residue subjected to silica gel chromatography, eluting with hexane. Fractions containing product were combined and concentrated under reduced pressure to provide 61% of the desired compound.

後処理

  1. temperatureat reflux for 13 hours
  2. concentrationThe reaction mixture was concentrated under reduced pressure
  3. washeluting with hexane
  4. additionFractions containing product
  5. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-43e0605e74b84098bd445cb921c3dbab
出典データセット
uspto-grants-2005_11
特許番号
US06967201B1

関連ノート

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