Hydrochloric Acid → 2-Propoxybenzoic Acid
反応式
[CH2:1]([O:4][C:5]1[CH:14]=[CH:13][CH:12]=[CH:11][C:6]=1[C:7]([O:9]C)=[O:8])[CH2:2][CH3:3].[OH-].[Na+].Cl>CO>[CH2:1]([O:4][C:5]1[CH:14]=[CH:13][CH:12]=[CH:11][C:6]=1[C:7]([OH:9])=[O:8])[CH2:2][CH3:3]参加物
5
反応条件
- 温度
- 60 °C
実験手順
To a solution of methyl 2-(propyloxy)benzoate (841 mg) in methanol (20 ml) was added 2N sodium hydroxide solution (5 ml) and the mixture was stirred at 60° C. for 2 hours. The reaction mixture was acidified with 6N hydrochloric acid to pH 4 and organic solvent was removed by evaporation. The aqueous layer was diluted with water and extracted with chloroform. The extract was washed with brine, dried over magnesium sulfate, and evaporated in vacuo to give 2-(propyloxy)benzoic acid as colorless oil (756 mg).
後処理
- customwas removed by evaporation
- additionThe aqueous layer was diluted with water
- extractionextracted with chloroform
- washThe extract was washed with brine
- dry with materialdried over magnesium sulfate
- customevaporated in vacuo
出典と根拠
- ORDレコード
- ord-56a5c324676a4d0897f0aba5a1cacc35
- 出典データセット
- uspto-grants-2005_11
- 特許番号
- US06967197B2
反応ノート
読み込み中…