Hydrochloric Acid → HCID 69744946、化合物

反応式

C(OC([N:8]1[CH2:14][CH2:13][C@:12]([CH2:29][C:30]([O:32][C:33]([CH3:36])([CH3:35])[CH3:34])=[O:31])([C:15]2[S:16][C:17]([C:20]3[CH:25]=[CH:24][C:23]([CH2:26][CH2:27][CH3:28])=[CH:22][CH:21]=3)=[CH:18][CH:19]=2)[S:11](=[O:38])(=[O:37])[CH2:10][CH2:9]1)=O)(C)(C)C.Cl.C(=O)(O)[O-].[Na+]>O1CCCC1>[CH2:26]([C:23]1[CH:22]=[CH:21][C:20]([C:17]2[S:16][C:15]([C@:12]3([CH2:29][C:30]([O:32][C:33]([CH3:34])([CH3:36])[CH3:35])=[O:31])[S:11](=[O:38])(=[O:37])[CH2:10][CH2:9][NH:8][CH2:14][CH2:13]3)=[CH:19][CH:18]=2)=[CH:25][CH:24]=1)[CH2:27][CH3:28]

参加物

実験手順

To a solution of t-butyl 2-[(S)-4-t-butoxycarbonyl-7-(5-(4-propylphenyl)-2-thienyl)-1,1-dioxoperhydro-1,4-thiazepin-7-yl]acetate (10.4 g) in tetrahydrofuran (120 ml) was added conc. hydrochloric acid (30 ml) in tetrahydrofuran (30 ml) under ice-water cooling and the mixture was stirred at ambient temperature for 15 hours. The mixture was basified with saturated sodium bicarbonate solution and extracted with ethyl acetate. The organic layer was separated, washed with brine, dried over magnesium sulfate, and evaporated in vacuo to give t-butyl 2-[(S)-7-(5-(4-propylphenyl)-2-thienyl)-1,1-dioxoperhydro-1,4-thiazepin-7-yl]acetate (8.94 g) as yellow oil.