Ethyl 3-methyl-3-pyridin-4-ylprop-2-enoate → Ethyl 3-(pyridin-4-yl)butanoate
反応式
[CH3:1][C:2]([C:9]1[CH:14]=[CH:13][N:12]=[CH:11][CH:10]=1)=[CH:3][C:4]([O:6][CH2:7][CH3:8])=[O:5]>C(O)C.[Pd]>[CH3:1][CH:2]([C:9]1[CH:10]=[CH:11][N:12]=[CH:13][CH:14]=1)[CH2:3][C:4]([O:6][CH2:7][CH3:8])=[O:5]参加物
4
実験手順
To a solution of ethyl 3-methyl-3-pyridin-4-ylprop-2-enoate (Method 9; 8.4 g, 44 mmol) in ethanol (150 ml) was added 5% palladium on charcoal. The mixture was stirred under an atmosphere of hydrogen for 18 hours. The mixture was filtered through diatomaceous earth and the filtrate evaporated to leave a colourless oil. The crude product was purified by chromatography eluting with 30-50% EtOAc in hexane to give the product as a colourless oil. M/z 194.
後処理
- filtrationThe mixture was filtered through diatomaceous earth
- customthe filtrate evaporated
- customto leave a colourless oil
- customThe crude product was purified by chromatography
- washeluting with 30-50% EtOAc in hexane
出典と根拠
- ORDレコード
- ord-93d2f764bfec41f098ff46641a11cb07
- 出典データセット
- uspto-grants-2005_11
- 特許番号
- US06967216B2
反応ノート
読み込み中…