Pyridine → HCID 69355802、化合物

HRID 1064080ノート

反応式

HRID 1064080 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([OH:12])=O)[CH:5]=[CH:6][C:7]=1[Cl:8].[N:13]1[CH:18]=[CH:17][C:16]([CH:19]=O)=[CH:15][CH:14]=1.[C:21]([O:24]C(=O)C)(=[O:23])C.N1C=CC=CC=1>C(OCC)(=O)C.O>[Cl:1][C:2]1[CH:3]=[C:4]([C:9](=[CH:19][C:16]2[CH:15]=[CH:14][N:13]=[CH:18][CH:17]=2)[C:10](=[O:12])[C:21]([OH:24])=[O:23])[CH:5]=[CH:6][C:7]=1[Cl:8]

参加物

7

反応物 4

HCID 1049PyridineHCID 7918Acetic AnhydrideHCID 133894-PyridinecarboxaldehydeHCID 798743,4-Dichlorophenylacetic acid

生成物 1

HCID 69355802HCID 69355802、化合物

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 8857Ethyl Acetate溶媒

反応条件

温度
120 °C

実験手順

To mixture of (3,4-diChloro-phenyl)-acetic acid 10.3 g and pyridine-4-carbaldehyde 5.25 mL was added acetic anhydride 6 mL and pyridine 6 mL. The reaction mixture was heated to 120° C. for 2 hours and cooled down to room temperature. Water and ethyl acetate were added. The solid formed was filtered, washed with water and ethyl acetate and dried to afford the title compound 10.2 g as a light yellow solid. MS (ES+): 292 (M+H)+.

後処理

  1. temperaturecooled down to room temperature
  2. customThe solid formed
  3. filtrationwas filtered
  4. washwashed with water and ethyl acetate
  5. customdried

出典と根拠

ORDレコード
ord-f6a6dd6deb874fbe92a88efe556fddc6
出典データセット
uspto-grants-2005_11
特許番号
US06967254B2

反応ノート

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