3-Methylbenzoyl chloride → HCID 11156487、化合物

HRID 1064353ノート

反応式

HRID 1064353 の反応式
[NH2:1][C:2]1[C:11]([C:12]#[N:13])=[C:10]([NH:14][CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[CH3:22][C:23]1[CH:24]=[C:25]([CH:29]=[CH:30][CH:31]=1)[C:26](Cl)=[O:27]>N1C=CC=CC=1>[CH3:22][C:23]1[CH:24]=[C:25]([CH:29]=[CH:30][CH:31]=1)[C:26]([N:1]([C:26](=[O:27])[C:25]1[CH:29]=[CH:30][CH:31]=[C:23]([CH3:22])[CH:24]=1)[C:2]1[C:11]([C:12]#[N:13])=[C:10]([NH:14][CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1)=[O:27]

参加物

4

反応物 2

HCID 743753-Methylbenzoyl chlorideHCID 112888282-Amino-3-cyano-4-benzylaminoquinoline

生成物 1

HCID 11156487HCID 11156487、化合物

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

反応条件

温度
0 °C

実験手順

To the solution of 5 g of 2-amino-3-cyano-4-benzylaminoquinoline in 30 ml of pyridine 6 ml of 3-methylbenzoyl chloride are dropped, under stirring at 0° C. The reaction mixture is stirred at 80° C. for 8 hour, then it is poured onto 150 ml of ice-water. The precipitate is filtered off, washed twice with 40 ml of water. The resulting white crystalline material is recrystallized from 200 ml of ethanol to give 9.2 g of the title compound, mp.: 234° C.

後処理

  1. stirringThe reaction mixture is stirred at 80° C. for 8 hour
  2. filtrationThe precipitate is filtered off
  3. washwashed twice with 40 ml of water
  4. customThe resulting white crystalline material is recrystallized from 200 ml of ethanol

出典と根拠

ORDレコード
ord-7067f38f0aae444aa9bfe75d70071d65
出典データセット
uspto-grants-2005_11
特許番号
US06969723B2

反応ノート

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