3-Cyanobenzene-1-sulfonyl chloride → cis-1-(3-Cyanobenzenesulphonyl)-2,6-dimethyl-4-phenylmethylpiperazine

HRID 1064596ノート

反応式

HRID 1064596 の反応式
[CH2:1]([N:8]1[CH2:13][C@@H:12]([CH3:14])[NH:11][C@@H:10]([CH3:15])[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:16]([C:18]1[CH:19]=[C:20]([S:24](Cl)(=[O:26])=[O:25])[CH:21]=[CH:22][CH:23]=1)#[N:17]>N1C=CC=CC=1>[C:16]([C:18]1[CH:19]=[C:20]([S:24]([N:11]2[C@H:10]([CH3:15])[CH2:9][N:8]([CH2:1][C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=3)[CH2:13][C@@H:12]2[CH3:14])(=[O:26])=[O:25])[CH:21]=[CH:22][CH:23]=1)#[N:17]

参加物

4

反応物 2

HCID 28013603-Cyanobenzene-1-sulfonyl chlorideHCID 12197174(3r,5s)-1-Benzyl-3,5-dimethylpiperazine

生成物 1

HCID 69746861cis-1-(3-Cyanobenzenesulphonyl)-2,6-dimethyl-4-phenylmethylpiperazine

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

A solution of cis-4-benzyl-2,6-dimethylpiperazine (1 g), 4-N,N-dimethylaminopyridine(0.54 g), 3-cyanobenzenesulphonyl chloride (2.13 g) in pyridine (3 ml) were stirred at ambient temperature. After 1 h the mixture was partitioned between dichloromethane and water. The organic phase further washed with brine, collected, dried, (MgSO4) and solvent evaporated under reduced pressure to leave the subtitle compound as an orange gum. Yield: 1 g

後処理

  1. customAfter 1 h the mixture was partitioned between dichloromethane and water
  2. washThe organic phase further washed with brine
  3. customcollected
  4. customdried
  5. custom(MgSO4) and solvent evaporated under reduced pressure

出典と根拠

ORDレコード
ord-d447eb12e2d34832b0a79827c2d5c615
出典データセット
uspto-grants-2005_11
特許番号
US06969713B2

反応ノート

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