Succinic Acid → HCID 20277158、化合物

HRID 1065085ノート

反応式

HRID 1065085 の反応式
[CH3:1][C:2]1([CH3:16])[CH:7]2[CH2:8][CH:3]1[CH2:4][CH2:5][CH:6]2[CH2:9][CH2:10][N:11]1[CH:15]=[CH:14][N:13]=[CH:12]1.[C:17]([OH:24])(=[O:23])[CH2:18][CH2:19][C:20]([OH:22])=[O:21]>C(O)C>[C:17]([OH:24])(=[O:23])[CH2:18][CH2:19][C:20]([OH:22])=[O:21].[CH3:1][C:2]1([CH3:16])[CH:7]2[CH2:8][CH:3]1[CH2:4][CH2:5][CH:6]2[CH2:9][CH2:10][N:11]1[CH:15]=[CH:14][N:13]=[CH:12]1

参加物

4

反応物 2

HCID 1110Succinic AcidHCID 20277152HCID 20277152、化合物

生成物 1

HCID 20277158HCID 20277158、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒2 回

実験手順

A solution of 1-[2-(6,6-dimethylbicyclo[3.1.1]heptan-2-yl)ethyl]imidazole (0.8 g, 3.67 mmol) in hot ethanol (10 ml) was added to a solution of succinic acid (0.4 g, 3.39 mmol) in hot ethanol. After boiling for 0.15 h, the reaction mixture was concentrated to afford a colourless oil which solidified on trituration with ethyl acetate/petroleum ether (b.p. 40°-60°) to a white solid. Recrystallisation of the solid from ethyl acetate/petroleum ether (b.p. 40°-60°) afforded 1-[2-(6,6-dimethylbicyclo[3.1.1]heptan-2-yl)ethyl]imidazole hydrogen succinate.

後処理

  1. concentrationthe reaction mixture was concentrated
  2. customto afford a colourless oil which
  3. customRecrystallisation of the solid from ethyl acetate/petroleum ether (b.p. 40°-60°)

出典と根拠

ORDレコード
ord-36974992c83948e6b8311b876c9b3e0a
出典データセット
uspto-grants-1982_05
特許番号
US04328234

反応ノート

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