Succinic anhydride → 4-[4-[2-(Acetylamino)propyl]phenyl]-4-oxobutanoic acid

HRID 1065204

反応式

HRID 1065204 の反応式
[CH3:1][CH:2]([NH:10][C:11](=[O:13])[CH3:12])[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[C:14]1(=[O:20])[O:19][C:17](=[O:18])[CH2:16][CH2:15]1.[Cl-].[Al+3].[Cl-].[Cl-]>C(Cl)Cl>[C:11]([NH:10][CH:2]([CH3:1])[CH2:3][C:4]1[CH:5]=[CH:6][C:7]([C:14](=[O:20])[CH2:15][CH2:16][C:17]([OH:19])=[O:18])=[CH:8][CH:9]=1)(=[O:13])[CH3:12]

参加物

5

反応物 3

HCID 7922Succinic anhydride2 回HCID 26660AcetylamphetamineHCID 6451240Aluminum(III) Chloride

生成物 1

HCID 128502534-[4-[2-(Acetylamino)propyl]phenyl]-4-oxobutanoic acid

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

In a one l., three necked, creased flask provided with a stirrer, thermometer, condenser topped with a drying tube and a short length of Gooch tubing connected to a small Erlenmeyer flask was placed 18.7 g (0.106 moles) of N-(alpha-methylphenethyl) acetamide, 15.9 g (0.159 moles) of succinic anhydride and 500 ml of dry methylene chloride. The flask and contents were cooled to 0°-5°, and from the Erlenmeyer flask through the Gooch tubing, 55.5 g (0.424 moles) of anhydrous aluminum chloride was added in small portions over a period of approximately 0.5 hour. A sharp exotherm occurred after each of the first additions, but the temperature was not allowed to exceed 8°. During the addition, the succinic anhydride slowly dissolved and gradually a grayish green gum was deposited. After five hours at 0°-5°, the cooling bath was removed, and the stirred mixture allowed to warm to room temperature (19°-22°), then stirred for another twenty-four hours. At the end of this time, the reaction mixture consisted of a reddish orange gum and a pale-colored solvent. The mixture was cooled in an ice bath, and with vigorous stirring 200 ml of 3 N hydrochloric acid added at 20°. The mixture was stirred until the color of the viscous red gum became grayish white. The stirrer was then stopped, the layers allowed to separate, and the lower methylene chloride layer removed by suction from the reaction vessel. Another 300 ml of methylene chloride was added to the flask, the contents stirred for five minutes, then allowed to settle and the lower layer drawn off as before.

後処理

  1. customprovided with a stirrer
  2. customthermometer, condenser topped with a drying tube
  3. temperatureThe flask and contents were cooled to 0°-5°
  4. customto exceed 8°
  5. additionDuring the addition
  6. customthe cooling bath was removed
  7. temperatureThe mixture was cooled in an ice bath
  8. stirringwith vigorous stirring 200 ml of 3 N hydrochloric acid
  9. additionadded at 20°
  10. stirringThe mixture was stirred until the color of the viscous red gum
  11. customto separate
  12. customthe lower methylene chloride layer removed by suction from the reaction vessel
  13. additionAnother 300 ml of methylene chloride was added to the flask
  14. stirringthe contents stirred for five minutes

出典と根拠

ORDレコード
ord-a7afcc57160b498fa1de8083f336c6b7
出典データセット
uspto-grants-1982_05
特許番号
US04329281

関連ノート

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