Dimethylamine → HCID 20540231、化合物

HRID 1065266ノート

反応式

HRID 1065266 の反応式
[CH3:1][NH:2][CH3:3].C(=O)([O-])[O-].[Na+].[Na+].O.[CH3:11][O:12][C:13]1[CH:18]=[CH:17][C:16]([C:19]2([C:29](Cl)=[O:30])[CH2:28][CH2:27][C:22]3([O:26][CH2:25][CH2:24][O:23]3)[CH2:21][CH2:20]2)=[CH:15][CH:14]=1>CC1C=CC=CC=1>[CH3:11][O:12][C:13]1[CH:18]=[CH:17][C:16]([C:19]2([C:29]([N:2]([CH3:3])[CH3:1])=[O:30])[CH2:28][CH2:27][C:22]3([O:26][CH2:25][CH2:24][O:23]3)[CH2:21][CH2:20]2)=[CH:15][CH:14]=1

参加物

6

反応物 4

HCID 674DimethylamineHCID 962WaterHCID 10340Sodium CarbonateHCID 20540243HCID 20540243、化合物

生成物 1

HCID 20540231HCID 20540231、化合物収率 100%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

To a stirred and cooled (<0° C.) mixture of 49.5 parts of N-methylmethanamine solution 40%, 93 parts of sodium carbonate and 1000 parts of water is added dropwise a solution of 124 parts of 8-(4-methoxyphenyl)-1,4-dioxaspiro[4,5]decane-8-carbonyl chloride in 675 parts of methylbenzene. Upon completion, stirring is continued overnight at room temperature. The layers are separated and the organic phase is washed with water, dried, filtered and evaporated, yielding 128 parts (100%) of 8-(4-methoxyphenyl)-N,N-dimethyl-1,4-dioxaspiro[4,5]decane-8-carboxamide as a residue.

後処理

  1. temperaturecooled
  2. stirringUpon completion, stirring
  3. customThe layers are separated
  4. washthe organic phase is washed with water
  5. customdried
  6. filtrationfiltered
  7. customevaporated

出典と根拠

ORDレコード
ord-57636b6782d74dd7b10a71b904a9c14c
出典データセット
uspto-grants-1982_05
特許番号
US04329353

反応ノート

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