Sodium Hydroxide → HCID 20540294、化合物

HRID 1065308ノート

反応式

HRID 1065308 の反応式
[OH-].[Na+].[C:3]([OH:7])(=[S:6])[CH2:4][CH3:5].[C:8]([NH:11][C:12](=[O:15])[CH2:13]Cl)(=[O:10])[CH3:9]>O>[C:8]([NH:11][C:12](=[O:15])[CH2:13][S:6][C:3](=[O:7])[CH2:4][CH3:5])(=[O:10])[CH3:9]

参加物

5

反応物 3

HCID 14798Sodium HydroxideHCID 2366697N-acetyl-2-chloroacetamideHCID 178460587HCID 178460587、化合物

生成物 1

HCID 20540294HCID 20540294、化合物

試薬・触媒・溶媒 1

HCID 962Water溶媒2 回

実験手順

To a solution of 4.0 g. (0.1 mole) of sodium hydroxide in 50 ml. of water, cooled in ice and having nitrogen bubbled therethrough, was added 9.5 g. (0.1 mole) of thiopropionic acid. The reaction mixture was stirred for 5 minutes, after which there was added 13.7 g. of N-acetyl-chloroacetamide in 50 ml. of water. The reaction mixture was heated on a steam bath for 10 minutes, then cooled, filtered, and air dried. The product was washed with ether/hexane (3:1) three times with 150 ml. each washing, and then air dried. The product was recrystallized from water to yield 8.0 g. of white crystals.

後処理

  1. custombubbled
  2. additionwas added 9.5 g
  3. additionafter which there was added 13.7 g
  4. temperatureThe reaction mixture was heated on a steam bath for 10 minutes
  5. temperaturecooled
  6. filtrationfiltered
  7. customair dried
  8. washThe product was washed with ether/hexane (3:1) three times with 150 ml
  9. customeach washing, and then air dried
  10. customThe product was recrystallized from water
  11. customto yield 8.0 g

出典と根拠

ORDレコード
ord-f236a1bdb66f41a9b1ed1ca4c314168f
出典データセット
uspto-grants-1982_05
特許番号
US04329363

反応ノート

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