Water → 2-Ethyl-[1,1'-biphenyl]-3-methanol

HRID 1065572ノート

反応式

HRID 1065572 の反応式
[CH2:1]([C:3]1[C:8]([C:9](O)=[O:10])=[CH:7][CH:6]=[CH:5][C:4]=1[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[CH3:2].O>O1CCCC1.C(Cl)Cl>[CH2:1]([C:3]1[C:8]([CH2:9][OH:10])=[CH:7][CH:6]=[CH:5][C:4]=1[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[CH3:2]

参加物

5

反応物 2

HCID 962WaterHCID 202706372-Ethyl-[1,1'-biphenyl]-3-carboxylic acid

生成物 1

HCID 202706032-Ethyl-[1,1'-biphenyl]-3-methanol収率 106.4%

試薬・触媒・溶媒 2

HCID 6344Dichloromethane溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

To a stirred solution of 2-ethyl-[1,1'-biphenyl]-3-carboxylic acid (2.1 g, 0.0093 mole) in 50 ml of tetrahydrofuran was added dropwise borane-tetrahydrofuran complex (1.6 g, 0.0186 mole). The reaction mixture was stirred at room temperature for approximately 18 hours. Water (6 ml) was slowly added to the reaction mixture and the solvent removed under reduced pressure to give a residue. The residue was dissolved in methylene chloride; the solution was washed with 1 N aqueous sodium hydroxide, dried over anhydrous magnesium sulfate, and filtered. The filtrate was evaporated under reduced pressure to give 2-ethyl-[1,1'-biphenyl]-3-methanol (2.1 g) as an oil. The ir and nmr spectra were consistent with the named compound.

後処理

  1. customthe solvent removed under reduced pressure
  2. customto give a residue
  3. washthe solution was washed with 1 N aqueous sodium hydroxide
  4. dry with materialdried over anhydrous magnesium sulfate
  5. filtrationfiltered
  6. customThe filtrate was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-8f27b7fd789d4a9a8797ed1f3ed4c8d1
出典データセット
uspto-grants-1982_05
特許番号
US04329518

反応ノート

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