Hydrochloric Acid → S,S-Hexanediyldi-L-cysteine

HRID 1065749ノート

反応式

HRID 1065749 の反応式
CS(O[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11]OS(C)(=O)=O)(=O)=O.Cl.[NH2:18][C@H:19]([C:22]([OH:24])=[O:23])[CH2:20][SH:21].[OH-:25].[Na+].Cl>O.C(O)C>[CH2:11]([S:21][CH2:20][C@@H:19]([C:22]([OH:23])=[O:25])[NH2:18])[CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][S:21][CH2:20][C@@H:19]([C:22]([OH:24])=[O:23])[NH2:18]

参加物

7

反応物 4

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 60960Cysteine HydrochlorideHCID 1457351,6-Hexanediol, dimethanesulfonate

生成物 1

HCID 53471696S,S-Hexanediyldi-L-cysteine

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 962Water溶媒

実験手順

At 70° C., under nitrogen, a mixture of 137 g of 1,6-hexanediyl dimethanesulfonate and 175.5 g of cysteine-hydrochloride monohydrated in 1.5 l of water containing a little ethanol is agitated. There is then slowly added a solution of 5 N NaOH so that the pH of the reaction mixture is maintained between 8.5 and 9.5. At the end of the reaction the mixture is acidified to pH 5.2 with a solution of HCl. The precipitate is filtered, washed thoroughly with water, then dried and analyzed.

後処理

  1. temperatureis maintained between 8.5 and 9.5
  2. customAt the end of the reaction the mixture
  3. filtrationThe precipitate is filtered
  4. washwashed thoroughly with water
  5. customdried

出典と根拠

ORDレコード
ord-6a78a057348846899f816142eb81995d
出典データセット
uspto-grants-1982_05
特許番号
US04331656

反応ノート

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