2-(Benzylamino)-5-(trifluoromethyl)benzenesulfonamide → HCID 11333908、化合物
反応式
C([NH:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][C:10]=1[S:19]([NH2:22])(=[O:21])=[O:20])C1C=CC=CC=1.[H][H]>CO.[Pd]>[NH2:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]([F:17])([F:16])[F:18])=[CH:11][C:10]=1[S:19]([NH2:22])(=[O:21])=[O:20]参加物
5
実験手順
A solution of 2-benzylamino-5-trifluoromethylbenzenesulfonamide (7.3 g) in methanol (80 mL) was supplemented with 10% Pd/C (0.73 g) and submitted to hydrogen under pressure (4 bars) during 90 min. at room temperature. The insoluble material was removed by filtration and the filtrate was concentrated to dryness. The residue was crystallized in methanol-water to give the title compound (yield: 5 g); m.p. 142-143° C.
後処理
- customThe insoluble material was removed by filtration
- concentrationthe filtrate was concentrated to dryness
- customThe residue was crystallized in methanol-water
出典と根拠
- ORDレコード
- ord-61f40d3017aa402187936c8fcb603b2f
- 出典データセット
- uspto-grants-2001_06
- 特許番号
- US06242443B1
反応ノート
読み込み中…