Hydrochloric Acid → 2-chloro-N-(5-methoxy-2-methylphenyl)acetamide

HRID 1066261

反応式

HRID 1066261 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([CH3:10])=[C:7]([CH:9]=1)[NH2:8].C(N(CC)CC)C.[Cl:18][CH2:19][C:20](Cl)=[O:21].Cl>ClCCl>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([CH3:10])=[C:7]([NH:8][C:20](=[O:21])[CH2:19][Cl:18])[CH:9]=1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 6577Chloroacetyl chlorideHCID 8471TriethylamineHCID 995005-Methoxy-o-toluidine

生成物 1

HCID 11328892-chloro-N-(5-methoxy-2-methylphenyl)acetamide

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of 5-methoxy-2-methylaniline (7.62 g) and triethylamine (15.5 ml) in dichloromethane (150 ml) at 0-5° C. was added chloroacetyl chloride (5.0 ml) dropwise and the ice bath removed. The resulting reaction mixture was stirred for 45 min before being poured into dil HCl and extracted with dichloromethane. Organic extracts were combined, washed with water, dried (Na2SO4) and concentrated to give a brown solid that was triturated with diethyl ether to leave the sub-title compound as a beige solid (5.7 g).

後処理

  1. customthe ice bath removed
  2. customThe resulting reaction mixture
  3. extractionextracted with dichloromethane
  4. washwashed with water
  5. dry with materialdried (Na2SO4)
  6. concentrationconcentrated
  7. customto give a brown solid that
  8. customwas triturated with diethyl ether

出典と根拠

ORDレコード
ord-dfa0a48bffc6424384cdfa0f59d777dd
出典データセット
uspto-grants-2001_06
特許番号
US06242470B1

関連ノート

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