Water → N-(n-pentanesulfonyl)-3-amino-4-nitrobenzamide

HRID 1066338ノート

反応式

HRID 1066338 の反応式
[CH2:1]([S:6]([NH:9][C:10](=[O:24])[C:11]1[CH:16]=[CH:15][C:14]([N+:17]([O-:19])=[O:18])=[C:13]([NH:20]C(=O)C)[CH:12]=1)(=[O:8])=[O:7])[CH2:2][CH2:3][CH2:4][CH3:5].O.[OH-].[Na+]>C(O)C>[CH2:1]([S:6]([NH:9][C:10](=[O:24])[C:11]1[CH:16]=[CH:15][C:14]([N+:17]([O-:19])=[O:18])=[C:13]([NH2:20])[CH:12]=1)(=[O:7])=[O:8])[CH2:2][CH2:3][CH2:4][CH3:5]

参加物

5

反応物 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 21198585N-(n-pentanesulfonyl)-3-(acetylamino)-4-nitrobenzamide

生成物 1

HCID 21198604N-(n-pentanesulfonyl)-3-amino-4-nitrobenzamide

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
47.5 °C

実験手順

The above partially purified product of N-(n-pentanesulfonyl)-3-(acetylamino)-4-nitrobenzamide was mixed with 300 ml of water and 500 ml of ethanol. Two-hundred grams of a 10%-sodium hydroxide aqueous solution were added thereto, and the mixture was stirred at 45 to 50° C. for 6 hours. The solvent (approx. 300 ml) was evaporated under reduced pressure. The resulting residue was neutralized with 10% hydrochloric acid aqueous solution and adjusted to pH 2 with diluted hydrochloric acid. The precipitated crystals were collected by filtration and dried to give 85.0 g of yellow crystals of N-(n-pentanesulfonyl)-3-amino-4-nitrobenzamide.

後処理

  1. customThe solvent (approx. 300 ml) was evaporated under reduced pressure
  2. filtrationThe precipitated crystals were collected by filtration
  3. customdried

出典と根拠

ORDレコード
ord-a720b1cead6a4e5ebdec248b4897d014
出典データセット
uspto-grants-2001_06
特許番号
US06242474B1

反応ノート

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