Ammonium Hydroxide → 5-Bromo-2-methoxybenzenesulphonamide
反応式
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([O:12][CH3:13])=[C:6]([S:8](Cl)(=[O:10])=[O:9])[CH:7]=1.[NH4+:14].[OH-]>C1COCC1.CCOC(C)=O>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([O:12][CH3:13])=[C:6]([S:8]([NH2:14])(=[O:10])=[O:9])[CH:7]=1参加物
5
実験手順
To 5-bromo-2-methoxybenzenesulfonyl chloride (45g; 157.6 mmol, from Lancaster Chemical) at 0° C. in THF, was added concentrated NH4OH (42.5 mL) and the reaction mixture was brought to r.t. for 2 h. The reaction mixture was diluted with EtOAc, extracted with NaHCO3 (2×), brine, and the organic phase was dried over MgSO4. The solvent was removed to give the title compound.
後処理
- extractionextracted with NaHCO3 (2×), brine
- dry with materialthe organic phase was dried over MgSO4
- customThe solvent was removed
出典と根拠
- ORDレコード
- ord-d088f16016da428485a0eb1a1e3a4582
- 出典データセット
- uspto-grants-2001_06
- 特許番号
- US06242493B1
反応ノート
読み込み中…