6-Methyl-3-nitro-5,6,7,8-tetrahydro-1,6-naphthyridine → 3-Amino-5,6,7,8-tetrahydro-6-methyl-1,6-naphthyridine
反応式
[CH3:1][N:2]1[CH2:11][CH2:10][C:9]2[N:8]=[CH:7][C:6]([N+:12]([O-])=O)=[CH:5][C:4]=2[CH2:3]1>CO.[Pd]>[NH2:12][C:6]1[CH:7]=[N:8][C:9]2[CH2:10][CH2:11][N:2]([CH3:1])[CH2:3][C:4]=2[CH:5]=1参加物
4
実験手順
6-Methyl-3-nitro-5,6,7,8-tetrahydro[1,6]naphthyridine (2.72 g, 1.41 mmol) was dissolved in methanol (100 ml) and treated with 10% palladium on carbon (1.0 g). The mixture was hydrogenated for 2 h. The catalyst was removed by filtration through Celite, the filter bed washed with methanol and the filtrate evaporated to dryness under reduced pressure to give a yellow solid, which was triturated under diethyl ether and the solids collected by filtration, washed with diethyl ether and dried in vacuo (1.89 g, 83%)
後処理
- customThe catalyst was removed by filtration through Celite
- washthe filter bed washed with methanol
- customthe filtrate evaporated to dryness under reduced pressure
- customto give a yellow solid, which
- customwas triturated under diethyl ether
- filtrationthe solids collected by filtration
- washwashed with diethyl ether
- customdried in vacuo (1.89 g, 83%)
出典と根拠
- ORDレコード
- ord-a125e8ccd5cb42348a1a4240cc00bad9
- 出典データセット
- uspto-grants-2001_06
- 特許番号
- US06245778B1
反応ノート
読み込み中…