Piperidine → 1-(Piperidin-1-yl)-4-(2-fluoro-5-bromobenzyloxy)butane

HRID 1066834ノート

反応式

HRID 1066834 の反応式
[F:1][C:2]1[CH:14]=[CH:13][C:12]([Br:15])=[CH:11][C:3]=1[CH2:4][O:5][CH2:6][CH2:7][CH2:8][CH2:9]Br.[NH:16]1[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]1>O1CCCC1.C(Cl)Cl>[N:16]1([CH2:9][CH2:8][CH2:7][CH2:6][O:5][CH2:4][C:3]2[CH:11]=[C:12]([Br:15])[CH:13]=[CH:14][C:2]=2[F:1])[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]1

参加物

5

反応物 2

HCID 8082PiperidineHCID 21196139HCID 21196139、化合物

生成物 1

HCID 211961091-(Piperidin-1-yl)-4-(2-fluoro-5-bromobenzyloxy)butane

試薬・触媒・溶媒 2

HCID 6344Dichloromethane溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

A solution of 4-(2-fluoro-5-bromobenzyloxy)butyl bromide (520 mg, 1.53 mmol) in tetrahydrofuran (8 ml) was treated with piperidine (1.5 ml, 15.3 mmol). The resulting reaction mixture was stirred for about 24 hours. The reaction mixture was then diluted with methylene chloride and washed with saturated sodium bicarbonate. The organic fraction was dried over sodium sulfate and the solvents were removed in vacuo. The desired title intermediate was further purified by radial chromatography.

後処理

  1. customThe resulting reaction mixture
  2. washwashed with saturated sodium bicarbonate
  3. dry with materialThe organic fraction was dried over sodium sulfate
  4. customthe solvents were removed in vacuo
  5. customThe desired title intermediate was further purified by radial chromatography

出典と根拠

ORDレコード
ord-ea1c3d25f6f8406f9103a277347bf27b
出典データセット
uspto-grants-2001_06
特許番号
US06245761B1

反応ノート

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