Ethanol → Ethyl 8-amino-2,3-dihydrobenzo[1,4]dioxine-5-carboxylate

反応式

S(Cl)(Cl)=O.[NH2:5][C:6]1[C:11]2[O:12][CH2:13][CH2:14][O:15][C:10]=2[C:9]([C:16]([OH:18])=[O:17])=[CH:8][CH:7]=1.[CH2:19](O)[CH3:20]>>[NH2:5][C:6]1[C:11]2[O:12][CH2:13][CH2:14][O:15][C:10]=2[C:9]([C:16]([O:18][CH2:19][CH3:20])=[O:17])=[CH:8][CH:7]=1

参加物

反応物 3

HCID 702Ethanol2 回

HCID 24386Thionyl Chloride

HCID 211934708-Amino-2,3-dihydrobenzo[b][1,4]dioxine-5-carboxylic acid

生成物 1

HCID 15817382Ethyl 8-amino-2,3-dihydrobenzo[1,4]dioxine-5-carboxylate

反応条件

温度: -40 °C

実験手順

23.5 g (0.198 mol) of thionyl chloride are introduced slowly into a 2 1 three-necked round-bottomed flask containing 772 ml of ethanol cooled to −40° C., with stirring, the stirring is continued at this temperature for 1 h, 38.6 g (0.198 mol) of 8-amino-2,3-dihydro-1,4-benzodioxine-5-carboxylic acid dissolved in 100 ml of ethanol are added slowly, over 15 min, and the mixture is allowed to warm to room temperature overnight.