Sodium Hydroxide → 1-methylindole-2,7-dicarboxylic Acid

HRID 1067765ノート

反応式

HRID 1067765 の反応式
[C:1]([C:5]1[CH:6]=[CH:7][CH:8]=[C:9]2[C:13]=1[N:12]([CH3:14])[C:11]([C:15]([O:17]CC)=[O:16])=[CH:10]2)([O:3]C)=[O:2].[OH-].[Na+]>C(O)C>[CH3:14][N:12]1[C:13]2[C:9](=[CH:8][CH:7]=[CH:6][C:5]=2[C:1]([OH:3])=[O:2])[CH:10]=[C:11]1[C:15]([OH:17])=[O:16]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 10825291Ethyl 7-carbomethoxy-1-methyl-2-indolecarboxylate

生成物 1

HCID 108465121-methylindole-2,7-dicarboxylic Acid収率 107.7%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of 5.20 g (19.9 mmol) of ethyl 7-carbomethoxy-1-methyl-2-indolecarboxylate, 90 ml of 2N sodium hydroxide and 150 ml of ethanol was refluxed for 3 hours. The reaction mixture was concentrated under reduced pressure and ice water was added to the residue. 2N hydrochloric acid was added to acidify the reaction mixture. The precipitated solid was filtered and dried under reduced pressure to give 4.70 g (>99%) of 1-methylindole-2,7-dicarboxylic acid.

後処理

  1. temperaturewas refluxed for 3 hours
  2. concentrationThe reaction mixture was concentrated under reduced pressure and ice water
  3. additionwas added to the residue
  4. addition2N hydrochloric acid was added
  5. filtrationThe precipitated solid was filtered
  6. customdried under reduced pressure

出典と根拠

ORDレコード
ord-abc21a79c3b040589527faeaf14517b9
出典データセット
uspto-grants-2001_06
特許番号
US06248772B1

反応ノート

読み込み中…