Guanidine Hydrochloride → HCID 178478910、化合物

HRID 1067796

反応式

HRID 1067796 の反応式
[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][C:7]([C:11]([O:13]C)=O)=[CH:8][CH:9]=2)[CH:4]=[CH:3]1.[ClH:15].[NH2:16][C:17]([NH2:19])=[NH:18].C[O-].[Na+]>CO>[ClH:15].[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][C:7]([C:11]([NH:18][C:17]([NH2:19])=[NH:16])=[O:13])=[CH:8][CH:9]=2)[CH:4]=[CH:3]1

参加物

5

反応物 3

HCID 5742Guanidine HydrochlorideHCID 10679201Methyl 1-methyl-1H-indole-5-carboxylateHCID 10942334Sodium Methoxide

生成物 1

HCID 178478910HCID 178478910、化合物収率 68.9%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

The reaction was carried out in a manner similar to Example 1 except for using 1.00 g (5.29 mmol) of methyl 1-methyl-5-indolecarboxylate, 5.05 g (52.9 mmol) of guanidine hydrochloride and 50 ml of a methanol solution of 2.85 g (52.9 mmol) of sodium methoxide. Thus 0.92 g (68.9%) of 1-methyl-5-indoloylguanidine hydrochloride was obtained.

出典と根拠

ORDレコード
ord-7ac5db2e75204f30954d940433b71b94
出典データセット
uspto-grants-2001_06
特許番号
US06248772B1

関連ノート

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