HCID 16073829、化合物 → HCID 6479235、化合物
反応式
[Cl:1][C:2]1[CH:28]=[CH:27][C:5]([CH2:6][NH:7][C:8]([C:10]2[C:19](=[O:20])[C:18]3[C:13](=[C:14]([F:25])[CH:15]=[C:16]([C:21]#[C:22][CH2:23][OH:24])[CH:17]=3)[N:12]([CH3:26])[CH:11]=2)=[O:9])=[CH:4][CH:3]=1>CO.C(Cl)Cl.[Pd]>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][NH:7][C:8]([C:10]2[C:19](=[O:20])[C:18]3[C:13](=[C:14]([F:25])[CH:15]=[C:16](/[CH:21]=[CH:22]\[CH2:23][OH:24])[CH:17]=3)[N:12]([CH3:26])[CH:11]=2)=[O:9])=[CH:27][CH:28]=1参加物
5
実験手順
A mixture of N-(4-chlorobenzyl)-8-fluoro-1,4-dihydro-6-(3-hydroxy-1-propynyl)-1-methyl-4-oxo-3-quinolinecarboxamide from Example No. 8 (0.200 g) and Pd/C (10%, 0.040 g) in MeOH (10 mL) and CH2Cl2 (10 mL) is placed on a Parr shaker under 50 psi of H2 for 6 h. The reaction mixture is filtered through Celite and concentrated in vacuo. Recrystallization from EtOAc gave the title compound as a solid.