Triethylamine → (2S,9R)-2-[(tert-Butoxycarbonyl)amino]-7-(carbobenzyloxy)-10-chloro-9-hydroxy-7-azadecanoic Acid tert-Butyl Ester
反応式
[C:1]([O:5][C:6](=[O:36])[C@@H:7]([NH:28][C:29]([O:31][C:32]([CH3:35])([CH3:34])[CH3:33])=[O:30])[CH2:8][CH2:9][CH2:10][CH2:11][N:12]([C:18]([O:20][CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)=[O:19])[CH2:13][C@H:14]([OH:17])[CH2:15][Cl:16])([CH3:4])([CH3:3])[CH3:2].C(OC(=O)[C@@H](NC(OC(C)(C)C)=O)CCCCNC[C@@H](O)CCl)(C)(C)C.ClC(OCC1C=CC=CC=1)=O.C(N(CC)CC)C>>[C:1]([O:5][C:6](=[O:36])[C@@H:7]([NH:28][C:29]([O:31][C:32]([CH3:35])([CH3:34])[CH3:33])=[O:30])[CH2:8][CH2:9][CH2:10][CH2:11][N:12]([C:18]([O:20][CH2:21][C:22]1[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=1)=[O:19])[CH2:13][C@@H:14]([OH:17])[CH2:15][Cl:16])([CH3:4])([CH3:3])[CH3:2]参加物
5
反応物 4
生成物 1
実験手順
According to the method described for the preparation of 13a, 12b (2.93 g, 7.42 mmol) was reacted with benzyl chloroformate (1.60 g, 9.38 mmol) and triethylamine (1.50 g, 14.81 mmol) to obtain 13b (3.35 g, 85%) as a colorless oil: 1H NMR δ 1.24-1.82 (m, 6H), 1.44 (s, 9H) 1.45 (s, 9H), 3.15-3.64 (m, 6H), 3.92 (m, 1H), 4.00 (m, 1H), 5.12 (m, 2H), 7.25-7.40 (m, 5H); 13C NMR δ 24.0, 28.3, 28.8, 32.5, 42.4, 51.3, 52.3, 55.7, 68.4, 71.0, 71.1, 80.4, 82.5, 129.0, 129.1, 129.6, 138.0, 158.1, 158.4, 173.7; HRMS m/z calcd for C26H42ClN2O7 529.2681, found 529.2691. Anal. calcd. for C26H41ClN2O7: C 59.03, H 7.81, N 5.29. Found: C 58.88, H 7.83, N 5.23. [α]23D−1.7°(c 0.98, CH3OH).
出典と根拠
- ORDレコード
- ord-a55b3faf10f644658769f49b06cc9689
- 出典データセット
- uspto-grants-2001_06
- 特許番号
- US06248866B1
反応ノート
読み込み中…