Hydroxyamine hydrochloride → 1-(4-((2,4-Difluorophenyl)-hydroxyimino-methyl)piperidin-1-yl)ethanone

HRID 1068147ノート

反応式

HRID 1068147 の反応式
[F:1][C:2]1[CH:18]=[C:17]([F:19])[CH:16]=[CH:15][C:3]=1[C:4]([CH:6]1[CH2:11][CH2:10][N:9]([C:12](=[O:14])[CH3:13])[CH2:8][CH2:7]1)=O.Cl.[NH2:21][OH:22].C([O-])(=O)C.[Na+]>CCO>[F:1][C:2]1[CH:18]=[C:17]([F:19])[CH:16]=[CH:15][C:3]=1[C:4](=[N:21][OH:22])[CH:6]1[CH2:11][CH2:10][N:9]([C:12](=[O:14])[CH3:13])[CH2:8][CH2:7]1

参加物

5

反応物 3

HCID 443297Hydroxyamine hydrochlorideHCID 517045Sodium AcetateHCID 27407071-Acetyl-4-(2',4'-difluorobenzoyl)piperidine

生成物 1

HCID 867570241-(4-((2,4-Difluorophenyl)-hydroxyimino-methyl)piperidin-1-yl)ethanone

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

The title compound was prepared from 1-(4-(2,4-difluoro-benzoyl)piperidin-1-yl)ethanone, hydroxylamine hydrochloride and sodium acetate in refluxing EtOH.

出典と根拠

ORDレコード
ord-9d76206c853e40cb8a895999c76ca2a1
出典データセット
uspto-grants-2001_06
特許番号
US06248755B1

反応ノート

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