Ethyl 1-phenylpiperidine-4-carboxylate → 1-Phenylpiperidine-4-carboxylic acid

HRID 1068427ノート

反応式

HRID 1068427 の反応式
[C:1]([CH:6]1[CH2:11][CH2:10][N:9]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH2:8][CH2:7]1)([O:3]CC)=[O:2].[OH-].[Na+]>CO>[C:1]([CH:6]1[CH2:7][CH2:8][N:9]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH2:10][CH2:11]1)([OH:3])=[O:2]

参加物

4

反応物 2

HCID 6470Ethyl 1-phenylpiperidine-4-carboxylateHCID 14798Sodium Hydroxide

生成物 1

HCID 30239901-Phenylpiperidine-4-carboxylic acid

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

The product from Step C was dissolved in methanol and 5% aqueous sodium hydroxide added. After 1 h, methanol was removed in vacuo, and the residue partitioned between ethyl acetate and 10% aqueous HCl. The organic layer was washed with saturated brine, and dried over MgSO4. Filtration and concentration provided the title compound.

後処理

  1. custommethanol was removed in vacuo
  2. customthe residue partitioned between ethyl acetate and 10% aqueous HCl
  3. washThe organic layer was washed with saturated brine
  4. dry with materialdried over MgSO4
  5. filtrationFiltration and concentration

出典と根拠

ORDレコード
ord-a170670efb9444dda237642fa0449b8a
出典データセット
uspto-grants-2001_06
特許番号
US06248756B1

反応ノート

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