Propylamine → n-Propyl-4-sulfamoylbenzamide

HRID 1068553

反応式

HRID 1068553 の反応式
[S:1]([C:5]1[CH:13]=[CH:12][C:8]([C:9]([OH:11])=O)=[CH:7][CH:6]=1)(=[O:4])(=[O:3])[NH2:2].[CH2:14]([NH2:17])[CH2:15][CH3:16]>O1CCCC1>[CH2:14]([NH:17][C:9](=[O:11])[C:8]1[CH:7]=[CH:6][C:5]([S:1](=[O:3])(=[O:4])[NH2:2])=[CH:13][CH:12]=1)[CH2:15][CH3:16]

参加物

4

反応物 2

HCID 7852PropylamineHCID 8739Carzenide

生成物 1

HCID 226552n-Propyl-4-sulfamoylbenzamide

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

At room temperature, 10 g (0.05 mol) of 4-sulfamoylbenzoic acid are dissolved in 100 ml of tetrahydrofuran and admixed with 8.1 g (0.05 mol) of N,N′-carbonyldiimidazole. After 30 minutes at room temperature and a further 30 minutes at reflux temperature, 2.9 g (0.05 mol) of propylamine are added at room temperature. After 2 hours, the reaction mixture is concentrated and stirred with water, the precipitate is filtered off with suction and dried.

後処理

  1. additionare added at room temperature
  2. waitAfter 2 hours
  3. concentrationthe reaction mixture is concentrated
  4. filtrationthe precipitate is filtered off with suction
  5. customdried

出典と根拠

ORDレコード
ord-9880f0541c30494580b99e574032fbc6
出典データセット
uspto-grants-2001_06
特許番号
US06251827B1

関連ノート

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