Nitric Acid → 1-Bromo-2,5-dichloro-4-nitrobenzene

HRID 1068605

反応式

HRID 1068605 の反応式
[Br:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[Cl:9].[N+:10]([O-])([OH:12])=[O:11]>>[Cl:9][C:3]1[CH:4]=[C:5]([N+:10]([O-:12])=[O:11])[C:6]([Cl:8])=[CH:7][C:2]=1[Br:1]

参加物

3

反応物 2

HCID 944Nitric AcidHCID 150332-Bromo-1,4-dichlorobenzene

生成物 1

HCID 211900161-Bromo-2,5-dichloro-4-nitrobenzene

実験手順

A solution of 2-bromo-1,4-dichlorobenzene (1.000 g, 4.443 mmol, Aldrich, used as received) in fuming HNO3 (7.0 mL) was stirred at 50° C. for 1.5 h and poured into ice (80 g). Yellowish white solid was filtered, washed with water (10 mL), and dried under vacuum to obtain 1.14 g (95%) of pure (CH NMR) title compound as a yellowish white powder; m.p. 50-53° C. (lit m.p. 57-58° C.; Fox, D. L. and Turner, E. E., J. Chem. Soc. 1859 (1930)); 1H NMR (CDCl3): δ 7.863 (s, 1H), 8.030 (s, 1H). This material was used as such for the next reaction.

後処理

  1. filtrationYellowish white solid was filtered
  2. washwashed with water (10 mL)
  3. customdried under vacuum

出典と根拠

ORDレコード
ord-4d74f826a7da43e5ab2804fc6036a716
出典データセット
uspto-grants-2001_06
特許番号
US06251903B1

関連ノート

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