Hydrochloric Acid → 1,2-Dihydro-1,4,7b-triazacyclopent[cd]inden-2-one
反応式
[C:1]([C:5]1[N:9]2[C:10]([NH2:14])=[CH:11][CH:12]=[CH:13][C:8]2=[N:7][CH:6]=1)(OC)=[O:2].C[O-].[Na+].CO.Cl>C(#N)C>[NH:14]1[C:10]2[N:9]3[C:8](=[N:7][CH:6]=[C:5]3[C:1]1=[O:2])[CH:13]=[CH:12][CH:11]=2参加物
5
実験手順
To a solution prepared by dissolving 1.44 g (7.0 mM) of 3-carbomethoxy-5-aminoimidazo[1,2-a]pyridine in 10 ml of acetonitrile followed by addition of 3.2 ml (14.0 mM) of 25% sodium methoxide-methanol and the mixture was refluxed for 1 hour. After completion of the reaction, 1.15 ml (14.0 mM) of 12N-hydrochloric acid was added to the reaction mixture under ice-cooling and the solvent was thoroughly distilled off under reduced pressure to provide 2.01 g (yield 100%) of a crude product as tan-colored solid.
後処理
- customTo a solution prepared
- temperaturethe mixture was refluxed for 1 hour
- additionwas added to the reaction mixture under ice-
- temperaturecooling
- distillationthe solvent was thoroughly distilled off under reduced pressure
出典と根拠
- ORDレコード
- ord-5bc9ebc966a049fbbb39d7ab1874fb36
- 出典データセット
- uspto-grants-2001_06
- 特許番号
- US06251905B1
反応ノート
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